Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone contains 191 amino acid residues with two disulfide bridges. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly).1-3 It reacts with GH-producing cells. Growth hormone receptors have been found in various non-pituitary cells, including that from hepatocellular carcinoma and various benign and malignant cutaneous lesions.4-6
1. Fukaya T, et al. Morphofunctional study of pituitary adenomas with acromegaly by immunoperoxidase technique and electron microscopy. Cancer. 1980; 45:1598-1603.
2. Kovacs K, et al. Adenoma of the human pituitary producing growth hormone and thyrotropin. A histologic, immunocytologic and fine-structural study. Virch Arch Pathol Anat. 1982; 395:59-68.
3. Cunha KS, et al. Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1. J Clin Pathol. 2003; 56:758-63.
4. Chopin LK, et al. Co-expression of GH and GHR isoforms in prostate cancer cell lines. Growth Horm IGF Res. 2002; 12:126-36.
5. Matsuno A et al. Histopathological analyses of silent pituitary somatotroph adenomas using immunohistochemistry, in situ hybridization and confocal laser scanning microscopic observation. Pathol Res Pract. 2001; 197:13-20.
6. Garcia-Caballero T, et al. Increased expression of growth hormone and prolactin receptors in hepatocellular carcinomas. Endocrine. 2000; 12:265-71.
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GH (EP267)
Rabbit Monoclonal
Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone contains 191 amino acid residues with two disulfide bridges. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly).1-3 It reacts with GH-producing cells. Growth hormone receptors have been found in various non-pituitary cells, including that from hepatocellular carcinoma and various benign and malignant cutaneous lesions.4-6
1. Fukaya T, et al. Morphofunctional study of pituitary adenomas with acromegaly by immunoperoxidase technique and electron microscopy. Cancer. 1980; 45:1598-1603.
2. Kovacs K, et al. Adenoma of the human pituitary producing growth hormone and thyrotropin. A histologic, immunocytologic and fine-structural study. Virch Arch Pathol Anat. 1982; 395:59-68.
3. Cunha KS, et al. Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1. J Clin Pathol. 2003; 56:758-63.
4. Chopin LK, et al. Co-expression of GH and GHR isoforms in prostate cancer cell lines. Growth Horm IGF Res. 2002; 12:126-36.
5. Matsuno A et al. Histopathological analyses of silent pituitary somatotroph adenomas using immunohistochemistry, in situ hybridization and confocal laser scanning microscopic observation. Pathol Res Pract. 2001; 197:13-20.
6. Garcia-Caballero T, et al. Increased expression of growth hormone and prolactin receptors in hepatocellular carcinomas. Endocrine. 2000; 12:265-71.
Rabbit Monoclonal
Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone contains 191 amino acid residues with two disulfide bridges. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly).1-3 It reacts with GH-producing cells. Growth hormone receptors have been found in various non-pituitary cells, including that from hepatocellular carcinoma and various benign and malignant cutaneous lesions.4-6
1. Fukaya T, et al. Morphofunctional study of pituitary adenomas with acromegaly by immunoperoxidase technique and electron microscopy. Cancer. 1980; 45:1598-1603.
2. Kovacs K, et al. Adenoma of the human pituitary producing growth hormone and thyrotropin. A histologic, immunocytologic and fine-structural study. Virch Arch Pathol Anat. 1982; 395:59-68.
3. Cunha KS, et al. Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1. J Clin Pathol. 2003; 56:758-63.
4. Chopin LK, et al. Co-expression of GH and GHR isoforms in prostate cancer cell lines. Growth Horm IGF Res. 2002; 12:126-36.
5. Matsuno A et al. Histopathological analyses of silent pituitary somatotroph adenomas using immunohistochemistry, in situ hybridization and confocal laser scanning microscopic observation. Pathol Res Pract. 2001; 197:13-20.
6. Garcia-Caballero T, et al. Increased expression of growth hormone and prolactin receptors in hepatocellular carcinomas. Endocrine. 2000; 12:265-71.
